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Endothelial nitric oxide synthase deficiency – implications for Alzheimer’s disease
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory loss and neuropathological hallmarks of amyloid- (A) plaques and neurofibrillary tangles, with aging as a major risk factor. ... -
Characterising T cell responses to chitosan hydrogel vaccines in an orthotopic mouse model of colorectal cancer
Anti-tumour T cell responses have a critical role in determining patient outcome in colorectal cancer (CRC). However, the generation of favourable immune responses in humans is poorly understood. Mouse models of CRC often ... -
An integrative approach to understanding antimicrobial resistance in New Zealand
Antimicrobial resistance (AMR) occurs when micro-organisms (including bacteria, viruses, fungi and parasites) survive exposure to a medicine that would usually kill them or halt their growth. This is a natural phenomenon ... -
Structural controls and geochemistry of hydrothermal fluid flow in an exhumed accretionary prism, Otago Schist, New Zealand
This study examines the structural controls, geochemistry, and potential source of an ancient hydrothermal fluid-flow system within the Otago Schist, using excellent exposures at Bruce Rocks, near Dunedin, as a case study. ... -
Sex, drugs, smokes and booze: What's driving teen trends? Describing and explaining trends in adolescent sexual behaviour, cannabis use, smoking and alcohol use in the early 21st century
Today’s adolescents are far less likely to smoke, drink, use drugs or be sexually active than their 1990s counterparts. My doctoral project set out to describe and explain trends in adolescent risk behaviours in the early ... -
Effect of Question Type and Exposure to Prior Information on Question Generation in a Simulated Interview Task
Given the key role that eyewitness evidence plays in criminal investigations, it is crucial that police investigators do not unduly constrain or contaminate witnesses’ reports. For this reason, best practice is to ask ... -
Anomalous Dissipation in Bose Gases: Analytic Theory of Energy Damping
The stochastic projected Gross-Pitaevskii equation (SPGPE) is a finite-temperature theory of Bose-Einstein condensate dynamics, utilizing a classical-field approach to describing the dynamics of a low-energy coherent ... -
Development of a viral chemokine binding protein as a diagnostic tool for chemokine detection.
Chemokines serve an integral role in the inflammatory response, specifically through the development of a chemotactic gradient which directs the trafficking of inflammatory leukocytes to the site of tissue damage or ... -
Non-Lamellar Liquid Crystalline Nanoparticles for Targeted Delivery of Endogenous Lipids to the Brain
Purpose: Bioactive endogenous lipids such as N-acylethanolamines (NAEs) and alkylglycerols have shown therapeutic potential in various neurological diseases and targeted brain drug delivery, respectively. However, their ... -
SciArt and Environmental Restoration: The role of intentionality in audience engagement
Science and art share a long history of interaction, and their practitioners contribute to wide-ranging collaborative projects. Interactions between these disciplines have demonstrated the value of using art to communicate ... -
Dentists’ knowledge and experiences of treating patients with Head and Neck Cancer.
Background In Australasia, Head and Neck Cancer (HNC) is more common and survivable than ever before. As a result, the population prevalence of HNC patients (including HNC survivors) in our communities is ever-increasing. ... -
Culture and Well-being: The Associations of Self-Construals with Life Satisfaction, Mental Health, and Distress
Self-construals (SC) are overarching schemas that define the way individuals construct themselves in relation to others (Markus & Kitayama, 1991). SCs are strongly influenced by cultural milieu. They can affect well-being ... -
Determinants of foreign investment and divestment
This thesis investigates determinants of bilateral foreign direct investment (FDI) and foreign divestment (FDiV), based on different theoretical models of these capital flows and a variety of estimation methods. It consists ... -
The effect of removing PsbJ in Synechocystis sp. PCC 6803 mutants that lack the extrinsic proteins of Photosystem II
Photosystem II (PS II) is the light-driven water-plastoquinone oxidoreductase of photosynthesis. PS II consists of 20 protein subunits including four core complexes forming the reaction centre, 13 additional low-molecular-weight ... -
Black light/whiteness rests my mind: Evocations of the spiritual in the art and practice of Ralph Hotere and Joanna Margaret Paul
This dissertation examines the art and practices of two Aotearoa New Zealand artists Ralph Hotere (1931-2013) and Joanna Margaret Paul (1945-2003) with a specific focus on their spiritual sensibilities, and in response to ... -
Closing Price Manipulation and Market Quality
This thesis examines the impact of closing price manipulation (“marking the close”) on several dimensions of equity market quality, including both the efficiency and integrity of equity markets. Marking the close is an ... -
Marine microbial community dynamics and responses to ocean acidification
Marine microbes, including both eukaryotes and prokaryotes, are the basal components of marine food webs and play a fundamental role in global biogeochemical cycling. Marine phytoplankton are responsible for approximately ... -
Characterisation of coastal fjords and buried glacial valleys at the sub-Antarctic Auckland Islands using high-frequency seismic data
High-resolution seismic surveying by the University of Otago has shown that the leeward side of the sub-Antarctic Auckland Islands (51° 44'S, 166° 06'E) is dominated by Quaternary glacial landforms that extend offshore. ... -
Investigation of ubiquitin transfer by RING E3 ligases RNF121 and RNF114
Ubiquitylation is a post-translational modification that modulates protein turnover, function and localisation. The attachment of ubiquitin is achieved by a sophisticated enzyme cascade. Specificity is provided by E3 ...