Abstract
The collagen mesh found in the extracellular matrix (ECM) of the myocardium plays a critical role in preserving tissue architecture and mechanical properties. Dynamic remodelling of the ECM occurs in different myocardial pathologies; this can manifest as a change in chamber geometry and/or mechanical properties which ultimately impacts overall cardiac performance. Therefore, precise quantification of collagen in the myocardium is of particular importance in histological characterisation of myocardial diseases.