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Arrhythmogenic and inotropic effects of long-chain acylcarnitines in the human heart
Conference presentation   Open access

Arrhythmogenic and inotropic effects of long-chain acylcarnitines in the human heart

H.M. Aitken-Buck, I. van Hout, J. Krause, P.J. Davis, R.W. Bunto, D.J. Parry, M.J.A. Williams, S. Coffey, T. Zeller, P.P. Jones, …
Otago Medical School Research Society Meeting - PhD Student Speaker Awards, 255th (Dunedin, New Zealand)
OMSRS - PhD Student Speaker Awards, New Zealand Medical Association
25/06/2021
Handle:
https://hdl.handle.net/10523/13419
Appears in  Otago Medical School Research Society

Abstract

Long-chain acylcarnitines (LCACs) are metabolites essential for lipid metabolism in the heart. Recent metabolomic studies have revealed that high plasma levels of LCACs, especially the 18:1 species, are associated with increased risk of cardiovascular diseases, including atrial arrhythmias. This study aimed to address whether LCAC 18:1 directly alters the susceptibility for arrhythmias and contractility of human heart muscle.
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