Brothers discordant for gout have differing DNA methylation patterns in inflammatory genes.

D. Gray; E. Ewers; A. Phipps-Green; A. Campbell; D.E. Porteous; S. Morris; R.M. Walker; N. Dalbeth; L.K. Stamp; T.R. Merriman; M.C. Thunders; T.J. Major

Brothers discordant for gout have differing DNA methylation patterns in inflammatory genes.

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Brothers discordant for gout have differing DNA methylation patterns in inflammatory genes.

D. Gray, E. Ewers, A. Phipps-Green, A. Campbell, D.E. Porteous, S. Morris, R.M. Walker, N. Dalbeth, L.K. Stamp, T.R. Merriman, …

Otago Medical School Research Society Meeting - Masters/Honours Student Speaker Awards, 264th (Dunedin, New Zealand)

OMSRS - Masters/Honours Student Speaker Awards, Otago Medical School Research Society

09/11/2022

Handle:

https://hdl.handle.net/10523/14729

Appears in Otago Medical School Research Society

Abstract

Gout is a complex disease affected by both genes and environment. Gout presents as painful flares which occur as a consequence of the innate immune-system inappropriately reacting to non-threatening environmental cues. Work in other inflammatory diseases has shown that DNA methylation can control the influence of environment on immune system responses. This study aimed to assess whether DNA methylation patterns influence gout risk in brothers discordant for gout.

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Record Identifier: 9926478423501891
Title: Brothers discordant for gout have differing DNA methylation patterns in inflammatory genes.
Creators: D. Gray
E. Ewers
A. Phipps-Green
A. Campbell
D.E. Porteous
S. Morris
R.M. Walker
N. Dalbeth
L.K. Stamp
T.R. Merriman
M.C. Thunders
T.J. Major
Contributors: Luke Wilson (Editor)
Helen Harcombe (Editor)
Daniel Ribeiro (Editor)
Laura Burga (Editor)
Jisha Antony (Editor)
Kate Morgaine (Editor)
Michael Garelja (Editor)
Adam Middleton (Editor)
Mudassir Anwar (Editor)
Trudy Milne (Editor)
Conference: Otago Medical School Research Society Meeting - Masters/Honours Student Speaker Awards, 264th (Dunedin, New Zealand)
Academic Unit: Medicine (DSM); Otago Medical School Research Society; Sir John Walsh Research Institute; Pathology and Molecular Medicine (DSM); School of Physiotherapy; Medicine (UOC); Public Health (DSM); Biochemistry; Pharmacology and Toxicology; Pathology and Molecular Medicine (UOW); Microbiology and Immunology; School of Pharmacy
Publisher: Otago Medical School Research Society
Date published ; e-published: 09/11/2022
Language: English
Resource Type ; Subtype: Conference presentation; Conference Abstract
Format: application/pdf