Abstract
Spinal cord injury (SCI) is a significant injury, and a burden to the patient, their family and to the healthcare system. The inflammatory response that follows the injury exasperates tissue damage and scarring, which prevents neuronal regeneration and patient recovery. Current in vivo models are problematic due to the extreme suffering of animals receiving the injury.
This study aimed to assess the extent and source of inflammation in the ex vivo model that has the potential to reduce animal usage and suffering.