Abstract
Damage to the skin that is extensive, irreversible, or unable to heal represents a major burden to patients and the health care system. Scaffolds and skin substitutes have been engineered, but not all provide the physical, mechanical, and biochemical features necessary for skin repair. Decellularisation methods enable isolation of native extracellular matrix (ECM) from animal tissue, providing biocompatible scaffolds, but at high costs. Decellularised plants provide cellulose matrices with physical similarities to ECM, and represent an abundant, ethical, low-cost alternative. This study aims to evaluate decellularised cellulose derived from seaweed species as scaffolds for skin repair.