Abstract
Estrogen is involved in normal male sexual function and can exert its effects on cells by activating estrogen receptors (ERs) such as ERa and ERb. Here, we explored the role of ERa activation on the sexual refractory period (i.e., the time when males cannot be sexually aroused after an ejaculation) and the Coolidge effect (i.e., the shortening of the refractory period when a novel sexual partner is introduced after ejaculation).
We investigated the effects of ERa administration on different parameters of sexual behaviours including mounting, intromission, and ejaculation in estrogen-deprived male rats.