Abstract
Dementia, characterised by progressive deterioration of cognitive functions, is a significant and growing health challenge, with a huge social and economic impact. Current available treatments have limited efficacy, warranting new targeted interventions. Several studies demonstrate dysfunctional electrical activity in brain-wide functional networks, particularly involving the dorsal anterior cingulate cortex (dACC), in individuals with cognitive impairments.
Non-invasive transcranial electrical stimulation, can normalize dysfunctional brain activity, thereby improve cognition. This pilot, double-blinded (participants and assessor) randomised sham-controlled parallel trial evaluated the safety and explored the immediate trend of effect of a novel, dACC targeted, high-definition transcranial infraslow pink noise stimulation technique (HD-tIPNS) on cognition in healthy older adults.