Abstract
Inhaled medication dissolves in the lung fluid (LF) before it is absorbed and has therapeutic actions. LF is a thin film of liquid that covers the surface of the respiratory system from nasal airways to alveolar region. Components of LF directly affect its viscosity and surface tension. Moreover, they have direct impact on solubility of inhaled medication.
We hypothesize that dissolution and absorption of inhaled medication depend upon the composition of LF that varies regionally in the lungs. In this study, we aimed to investigate the influence of components of LF such as mucus and surfactant on dissolution and absorption of medication by preparing and evaluating a series of artificial LFs.