Abstract
Globally, one in four couples are affected by infertility. Chronic stress is often a result, but also a possible cause of reproductive dysfunction. Regulation of gonadal function by luteinizing hormone (LH) from the pituitary gland is suppressed during chronic stress. However, the mechanisms are poorly understood. We investigated whether hypothalamic RFamide-related peptide (RFRP) neurons mediate this suppressive effect of glucocorticoids.