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Browsing Anatomy by Title
Now showing items 21-40 of 310
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An investigation to optimise stimulation parameters of Remote Ischaemic Conditioning with digital stimulation
Background: Many ongoing clinical trials are investigating the ability of Remote Ischemic Conditioning (RIC) to limit ischemic injury in major organs such as the heart and brain, focussing on cardiac surgery, myocardial ... -
Analysing the process of whole body regeneration in Botrylloides leachi
Regenerative capacity differs greatly across organisms, with many species only being able to regenerate a limited number of cell types. Unfortunately, from an evolutionary perspective, regenerative power correlates inversely ... -
Anatomical and functional characterization of hypothalamic insulin signaling in the metabolic control of reproductive function in mice
Central insulin signaling plays a key role in regulating the neuroendocrine reproductive axis. Mice exhibiting brain-specific insulin receptor gene (Insr) deletion (NIRKO mice) or diabetic insulin insufficiency display ... -
Anatomical aspects of iatrogenic nerve injury
Iatrogenic nerve injury causes distress and disability, often leading to litigation. To date, the scale and profile of these injuries can only be estimated from published case reports or series, and medico-legal claims ... -
Anatomical Characterisation of Prolactin Receptor Expression in the Developing Mouse Brain
Prolactin signalling through the prolactin receptor plays a significant role in many physiological processes. The diverse biological functions attributed to prolactin are largely dependent on the distribution of its receptor. ... -
Anatomy of microvenous valves of normal and venous ulcerated lower limbs
Venous disease is a very common disease that affects millions of people worldwide. While some of the factors that cause the development of varicose veins are well understood, the aetiology of venous ulceration is poorly ... -
Anti-Müllerian Hormone (AMH) Signalling in the Ovary
Female reproductive gametes, known as oocytes, are encased within specialized ovarian follicles that provide an optimal environment for oocyte maturation. The process of folliculogenesis, involving the developmental ... -
Anti-Müllerian hormone: A missing link in prostate cancer?
Prostate cancer is the most frequently diagnosed cancer in men in many countries including the USA, France, Germany and New Zealand (Health, 2002, Jemal et al., 2008, Ferlay et al., 2010). The growth of human prostate ... -
'Apai mai'anga i te aite'anga o te nui ki te atea: The effect of the Polynesian-specific CREBRFR458Q gene variant on pregnancy hormone levels in a mouse model
Lactogenic hormones (e.g., prolactin (PRL) and placental lactogens (PL) which act through the PRL receptor) drive maternal glucose adaptations during pregnancy. Dysfunction to this system contributes to the development of ... -
Arginine metabolism and tauopathies
Tauopathies refers to a group of neurodegenerative diseases characterized by the intracellular accumulation of hyperphosphorylated tau protein. Whereas Alzheimer’s disease (AD) is an example of secondary tauopathy, ... -
Arginine Metabolism and the Urea Cycle in Tauopathies
Dementia is a devastating health, economic, and social problem in New Zealand and globally. The growing burden of dementia is exacerbated by limited understanding of its pathogenesis and a scarcity of preventative and ... -
Assessing the efficacy of a fluorescent model of the ovarian reserve in mice
In mammalian females, germ cells proliferate exclusively in development resulting in a finite number of oocytes at birth which are kept in a dormant state within primordial follicles. The ovarian reserve (OR) is the ... -
Assessment of genetic variation in the threatened New Zealand sea lion, Phocarctos hookeri, and its association with fitness
The New Zealand sea lion (NZSL) is the rarest sea lion in the world and exists in relative isolation, primarily in New Zealand’s sub-Antarctic islands. Once widespread throughout New Zealand, the species suffered a population ... -
Assessment of the impacts of anthropogenic hybridisation in a threatened non-model bird species through the development of genomic resources with implications for conservation
Interspecific hybridisation—the breeding between distinct species—can contribute to species extinction due to wasted reproductive potential, outbreeding depression, and introgression of genetic material mediated by ... -
Balancing Safety and Developmental Potency: Assessing the Effect of Antioxidants and TET on Genomic Imprinting Stability.
Developmental potency represents the ability of undifferentiated cells to undergo transformation into differentiated cells, with specialised functions. The inner cell mass (ICM) of a blastocyst represents the most ... -
Behaviour and Movement Patterns of Dusky Dolphins (Lagenorhynchus obscurus) off Kaikoura, New Zealand: Effects of Tourism
Tourism targeting cetaceans near Kaikoura, New Zealand began in the late 1980s and five commercial operators offer tours to swim with or view pods of dusky dolphins. These dolphins are part of a large, mobile population ... -
Behavioural and Neurochemical Effects of Phencyclidine Treatment in Rats
Schizophrenia is a chronic mental disorder with prominent prefrontal and hippocampal dysfunction. Although the exact cause of schizophrenia is currently poorly understood, glutamatergic hypofunction and neurodevelopmental ... -
Biological characterisation of morphological alterations of the cornea following collagen cross-linking (CXL) treatment
Introduction: Keratoconus (KC) is a disease included in a broader range of conditions called corneal ectasia which leads to spontaneous, non-inflammatory, self-limiting ectasia of the cornea that results in localized corneal ... -
Body Weight Regulation During Pregnancy in the mouse
Leptin is an adipose-derived hormone that acts in the hypothalamus to regulate energy homeostasis by decreasing appetite and increasing metabolic rate. During pregnancy, food intake and fat deposition increases, despite ... -
Brain Regions Responding to Endogenous Prolactin during Pregnancy and Lactation
There is an increased incidence of dysfunctional mood disorders postpartum, affecting approximately 10-20% of all women. Postpartum mood disorders can have devastating effects on the mother, and lead to altered relationships ...